The Bulky 6-cm Barrel-Shaped Lesion of the Cervix: Primary Surgery and Postoperative Chemoradiation
Identifieur interne : 00A445 ( Main/Exploration ); précédent : 00A444; suivant : 00A446The Bulky 6-cm Barrel-Shaped Lesion of the Cervix: Primary Surgery and Postoperative Chemoradiation
Auteurs : Richard C. BoronowSource :
- Gynecologic Oncology [ 0090-8258 ] ; 2000.
Abstract
Objective. The purpose of this report is to detail what appears to be the largest reported experience of primary radical hysterectomy for bulky barrel-shaped cervical cancers of 6 cm or greater in diameter, followed in all instances by radiation therapy and chemotherapy. Methods. Twenty-two unselected cases were operated primarily. One had unresectable aortic node disease. Twenty-one were treated with intent to cure. All patients received extended field radiation therapy beginning 4 weeks after surgery. All patients also received infusion chemotherapy during weeks 1, 4, and 7 of their radiation therapy. Initially, 5-FU was the drug of choice; more recently, Platinol has been employed. Results. The Berkson–Gage relative survival of the total 22 cases was 71.3%. For the 21 cases treated with intent to cure, the survival was 75.4%. Complications were minimal. Conclusion. The experienced pelvic surgeon can accomplish this exercise with a high degree of safety; and this multimodality approach is offered as another therapeutic alternative for these high-risk patients.
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DOI: 10.1006/gyno.2000.5911
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